EFTA02667790.pdf

From: jeffrey E. <[email protected]> Sent: Wednesday, December 7, 2016 5:26 PM To: Donald Rubin Subject: Re: Placebo effects, EB, etc. ar you around on the weekend in cambridge.? =C24) On We=, Dec 7, 2016 at 1:10 PM, Donald Rubin .vrote:=br> On Dec 7, 2016, at 10:38 AM, jeffrey E. &l=;jeevacation@gm=il.com <mailto:[email protected]» wrote: three way skype for 3. and yes 1=face to face On Wed Dec 7 2016 at 11:37 AM, Donald Rubin target="_blank /=pan> wrote: Different ways to follow up. 1. =The next time that we're in the same town, we could talk about the=statistical ideas underlying ways to disentangle placebo effects from biol=gical effects of drugs and why that's important for FDA approvals =nd for prescripts in the docs office — different answers, I think.=/div> 2. I can send some recent things on the top=c of placebo response, which are still not that wonderfully written. =div> 3. If interested in exploring investing in EB, I =an put you in touch with Adriaan, who lives in Amsterdam. </=iv> Are any of these appealing? I prefer 1 to 2. I think a=face to face version of 3 could be arranged either here or there. let me know. On Dec 7, 2016, at 9:35 AM, jeffrey E. <[email protected] <mailto:[email protected]» wrote: =br class="m_-6698346136610420412m_-1196805788815373682Apple-interchange- =ewline"> I'm always interested in unique idea EFTA_R1_01919683 EFTA02667790  On Wed, Dec 7, 2016 at 10:12 AM D=nald Rubin wrote: Hello Jeffrey, I'm glad that Martin has put us in touch for a couple of r=asons. First, I think we have some mutual interests concerning the c=mplications of doing experiments with humans, rather than plants or animal= or tires. One complication is noncompliance with the assigned treat=ent, which we briefly discussed at the dinner, but the more interesting on= is the placebo effect, which can be gigantic, for example in "via=ra" type studies, which we didn't get around to discussing=except indirectly in the context of the Emotional Brain (EB) female viagra=issue. More generally, this is related to FDA standards for approving drugs= A slight aside: in January I'm one of three people getting=honorary degrees from the Medical Faculty of the University of Uppsala in =weden, where one of the others is Robert Califf, the current Commissioner =f the FDA (the other is Marcia McNutt, the current President of the Nation=l Academy of Sciences), so I should get the chance to bend his ear at vari=us meals (a former commissioner — under Bush II — was a pa=tial PhD student of mine when he was getting his MD at Harvard and his PhD=in Econ at MIT, and remains a good friend: Mark McClellen, who is interest=d in this stuff and remains quite influential in DC, I think). But the reas=n for rambling about the FDA and placebo effects is the following. T=is morning I just had an exchange of emails with the CEO of EB, whom I4>=804, ve known and worked with for about three years, Adriaan Tuiten. =He wrote that FDA has agreed with EB's proposal for more trials, a=d the EB board of directors just approved the issuance of about 12 million=Euros in stock to pay for these trials. Adriaan thinks that they may=have enough connections now, but would you be interested in participating?=C2* I already have some stock, which I earned though consulting. = think EB is interesting but still needs more wisdom when it comes to thei= statistics (I've been to FDA with them two or three times, and I =hink they still need help with some of their ideas e.g., using SNPs).41)=A0 If interested in tossing some money their way, let me know. In any case, I very=much enjoyed our last conversations, and I look forward to seeing you agai=, either in Cambridge or in NYC, which I'll probably get to in the=next couple of weeks. Best wishes, Don Donald B. Rubin John L. Loeb P=ofessor of Statistics Department of Statistics, Harvard University 2 EFTA_R1_01919684 EFTA02667791  On Dec 2, 2016, at 9:41 AM, jeffrey E.=<[email protected]<=a» wrote: <mailto:[email protected]> great On Fri, Dec 2, 2016 at 9:40 AM, Donald Rubin wrote: =br class="m_-6698346136610420412m_-1196805788815373682gmail_msg"> <=r class="m_-6698346136610420412m_-1196805788815373682gmail_msg"> =Iso, Martin, should we try to touch base on Monday? The rest of the =eek is pretty much shot for me with visitors. Best, Don > On Dec 2,=2016, at 9:32 AM, Nowak, Martin A wrote: > Don=, Jeffrey > I would like to put you in direct email contact. 3 EFTA_R1_01919685 EFTA02667792  ><=r class="m_-6698346136610420412m_-1196805788815373682gmail_msg"> =gt; also cc Lesley. >m please note The information contained in=this communication is confidential, may be attorney-client privileged, may constitute insi=e information, and is intended only for the use of the addressee. It is the proper=y of JE= Unauth=rized use, disclosure or copying of this communication or any part thereof is stri=tly prohibited and may be unlawful. If you have received this communication in error, plea=e notify us immediately by return e-mail or by e-mail to [email protected] <mailto:[email protected]> , and destroy this communication an= all copies thereof, including all attachments. copyright -all rights reserved 4 EFTA_R1_01919686 EFTA02667793  Q=AO please note The information contained in this communicati=n is confidential, may be attorney-client privileged, may constitute=inside information, and is intended only for the use of the addressee. =t is the property of JEE Unauthorized use, disclosure or copying of =his communication or any part thereof is strictly prohibited and may=be unlawful. If you have received this communication in error, please n=tify us immediately by return e-mail or by e-mail to [email protected] <mailto:[email protected]> , and =estroy this communication and all copies thereof, including all attachm=nts. copyright -all rights reserved p=ease note The information contained in this communication is co=fidential, may be attorney-client privileged, may constitute inside inf=rmation, and is intended only for the use of the addressee. It is the p=operty of JEE Unauthorized use, disclosure or copying of this com=unication or any part thereof is strictly prohibited and may be unlawfu=. If you have received this communication in error, please notify us im=ediately by return e-mail or by e-mail to [email protected] <mailto:jeevacation=gmail.com> , and destroy thi= communication and all copies thereof, including all attachments. copyr=ght -all rights reserved 5 EFTA_R1_01919687 EFTA02667794