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From: Faculty of 1000 < To: Jeff Epstein <[email protected]> Subject: F1000 March 2011 update: Mitotic Hijacker Date: Thu, 10 Mar 2011 16:37:49 +0000 If you're having trouble viewing this message, click to view in your default browser. ££1000 Monthly Update Evaluations Rankings Reports Posters Magazine Faculty March 2011 ;`‘clow Editors dow Top Fcatures;:ir 7 L;dow Reports2I-dow Posters facebo;:,' link gjtwi gjyoutu n Choice ok link ed-in ter be link link link Editor's Choice New this Month Mitotic Hijacker How a parasite sneakily 1,204 ensures its own Evaluations added replication. 7 Articles that Change Clinical Practice 14 Articles with an F1000 Factor of 11+ Current Issue Immunology: Drug Discovery: Physiology: Come Inside Bitter Pill Calcium Kicks latest issue Antibodies can block Bitter-tasting molecules Calcium channel disease spread from inside relax bronchial muscles. regulation in fight-or-flight a cell. response. F1000 Features to2 Infographic: Epigenetics -A Primer Epigenetic effects regulate the activation or repression of genes in many ways. Here are a few of the molecular tricks, illustrated. Stefan Kubicek EFTA00682356 Gr Ready, Reset, Go Rudolf Jaenisch enjoys Epigenetic Changes in Cancer The study of how covalent marks on climbing mountains. DNA and histones are involved in the rafting rapids, and origin and spread of cancer cells is also unraveling the secrets of leading to new therapeutic strategies. pluripotency -- knowledge Mane! Esteller that could someday lead to personalized Environmental Impact regenerative medicine. Research in behavioral epigenetics is Karen Hopkin seeking evidence that links experience to biochemistry to gene expression and back out again. David Berreby One on One: Imprinting Epigenetics and The Footprints of Diversity Society Winter Joachim Messing talks Did Erasmus Darwin Epigenetic marks laid Best Places to Work for Postdocs, about how genomic foreshadow the tweaking down during the cold 2011 imprinting may be a strong of his grandson's months of the year allow Setting up your own scientific driver of diversity. Cristina paradigm? flowering in spring and laboratory is no easy task, but this Luiggi Andrew D. Ellington summer. year's respondents are using their Ralf M011er and Justin postdoc experiences to prepare for the Goodrich challenge. Cristina Luiggi Naturally Selected Top 7 Evaluated Articles top Desmond Julian. who invented the concept of the coronary care unit, talks A snapshot of the highest-ranked articles from a 30-day period. about the importance of charity- funded research, prevention of heart 1 Drug helps, doesn't hurt, lung disease Respiratory distress syndrome patients treated with a neuromuscular blocker are disease, and the British Heart more likely than those on a placebo to survive 90 days. and show no increase in Foundation's 'Mending Broken muscle weakness - a common concern among doctors. Hearts' campaign. 2 Skip the surgery? Recommend a Free 30-day Trial A nonsurgical treatment for severe aortic stenosis. a type of heart disease to your Librarian characterized by the narrowing of the aortic valve opening, may provide an alternative for patients who are not candidates for open-heart surgery. The You can use our online form to send treatment replaces the aortic valve through a catheter. your recommendation. Alternatively. you may qualify for free access via 3 How T regs limit inflammation HINARI or Faculty Member T regulatory cells can multiply their numbers by secreting the cytokine interleukin sponsorship. IL-35, which converts the population of killer T cells into regulatory cells that suppress inflammation, providing a new explanation for how inflammation is reeled in after an infection is cleared. 4 Natural helpers fight infection A novel population of innate immune cells, identified in the gut adipose tissue of humans and mice and nicknamed "natural helper cells." produce large amounts of cytokines and may play an important role in fighting off parasites. 5 Cells sticking together In response to tension from adjacent cells, alpha-catenin, a cell adhesion protein, recruits actin binding proteins to strengthen cell-to-cell junctions, rapidly reacting to rearrangements in the local environment. 6 Silent effects Mutations in exons that do not change protein sequences can still have dramatic effects on gene expression in E. coli. Surprisingly, these effects are caused by EFTA00682357  changes in mRNA stability, not by codon bias. 7 Rat dad's diet affects pups Male rats fed a high-fat diet had daughters with diabetes-like beta-cell dysfuncfion, showing, for the first time in mammals, that environment of the father can influence the phenotype of the offspring. This F1000 Top 7 is a snapshot of the highest-ranked articles from a 30-day period in the previous month, described by The Scientist reporting team. See also Top 7s in Molecular Biology, Genetics and Genomics, Biochemistry and Cell Biology To see the latest rankings. visit Reports top The latest peer-reviewed F1000 Reports articles, published in F1000's two PubMed- indexed journals, are now available to view. Medulloblastoma: Laminar fate advances and specification in the challenges cerebral cortex Martine F. Roussel and Nicolas Gaspard and Giles Robinson Pierre Vanderhaeghen The role of blood flow Clostridium difficile-a in determining the moving target sites of atherosclerotic Glenn S. Tillotson and plaques Joni Tillotson Narges Amini, Amalia de Luca. Christina M. Warboys and Paul C. Evans F1000 Posters top Evaluated Poster of the Month Neuroscience Gy Role of dopamine and serotonin receptors in medial prefrontal and orbitofrontal cortex on impulsive choice in rats Gipson et al. Based on: Neuroscience 2010 meeting. Evaluated by Trevor W Robbins, University of Cambridge, UK Summary I Poster I Evaluation Recent conferences covered include: • 23rd Lorne Cancer Conference 2011 • Biochemical Society 2011 - Recent Advances in Membrane Biochemistry • Biochemical Society 2011 - Stress Responses - Molecules, Organisms and Environment ;t' EFTA00682358 You have received this message becauseyou asked to receive updates from Faculty of 1000. 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