EFTA02706138.pdf

From: Faculty of 1000 <[email protected]> Sent: Wednesday, December 5, 2012 3:16 PM To: [email protected] Subject: Season's greetings! Reconstructing a functioning thyroid using ESCs, and other interesting articles. <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> To ensure you receive emails from Faculty of 1000, add [email protected] <mailto:[email protected]> to your safelist. <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> <http://p4trc.emv2.com/HS?a=ENX7CqkWrP9- 8SA9MlUatd3nGHxKLTN8D_cStGb5lw8W0bBhOG5mpqVsje_HhdBmMIEO> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> ADVERTISEMENT chttp://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> F1000 Prime <http://p4trc.emv2.com/HS?a=ENX7CqkWrP9- 8SA9MlUatd3nGHxKLTN8DPcStGb5lw8WObBh0G5mpqVsje_HhdBmMIEP> F1000 Trials chttp://p4trc.emv2.com/HS?a=ENX7CqkWrP9- 8SA9MKJatd3nGHxKLTN8DfcStGb5lw8WObBh0G5mpqVsje_HhdBm MIEM> F1000 Research <http://p4trc.emv2.com/HS?a=ENX7CqkWrP9- 8SA9MKJatd3nGHxKLTN8AvcStGb5lw8WObBh0G5mpqVsje_HhdBmMIEN> F1000 Posters <http://p4trc.emv2.com/HS?a=ENX7CqkWrP9- 8SA9M lOatd3nGHxKLTN8A_cStGb5lw8W0bBhOG5mpqVsje_HhriBmMIES> Having trouble? View in your browser. chttp://p4trc.emv2.com/HM?a=ENX7CqkWrP9- 8SA9MKJatd3nGHxKLTP1kvcStGb5lw8WObBh0G5mpqVsje_HhdBmMIAU> chttp://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> <http://p4trc.emv2.com/HS?a=ENX7CqkWrP9- 8SA9MlUatd3nGHxKLTN8APcStGb5lw8WObBh0G5mpqVsje_HhdBmMIET> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> December 2012 chttp://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> chttp://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> F1000's faculty of over 5,000 expert scientists and clinical researchers, assisted by 5,000 associates, recommend the best articles in the life sciences. 1,515 recommendations were added in the last month, and you can see them all here <http://p4trc.emv2.com/HS?a=ENX7CqkWrP9- 8SA9MlUatd3nGHxKLTN8AfcStGb5lw8WObBh0G5mpqVsje_HhdBmMIEQ> . <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> EFTA_R1_02099223 EFTA02706138  <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> <http://p4trc.emv2.com/HS?a=ENX7CqkWrP9- 8SA9M lOatd3nGHxKLTN8BvcStGbSlw8W0bBhOG5mpqVsje_HhdBm MIER> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> Some of the articles that caught the attention of our F1000 Faculty this month. <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> Building thyroid from scratch <http://p4trc.emv2.com/HS?a=ENX7CqkWrP9- 8SA9MKJatd3nGHxKLTN8B_cStGb5lw8W0bBhOG5mpqVsje_HhdBmMIEW> The authors elegantly demonstrate that stem cells can be specifically reprogrammed to generate a functioning thyroid gland replacement. <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> Casting the neutrophil NETs wide <http://p4trc.emv2.com/HS?a=ENX7CqkWrP9- 8SA9MIOatd3nGHxKLTN8BPcStGb5lw8W0bBhOGSmpqVsje_HhdBmMIEX> This study highlights the multi-potent functional abilities of neutrophils in combatting bacterial infections by casting neutrophil extracellular traps (NETs). chttp://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> Colorectal cancer, an inflammatory issue <http://p4trc.emv2.com/HS?a=ENX7CqkWrP9- 8SA9MIUatd3nGHxKLTN8BfcStGbSlw8W0bBhOG5mpqVsje_HhdBmMIEU> A four-times-recommended study elucidates how microbiota composition can affect the development of colitis- associated cancer and vividly distinguishes genotoxicity and carcinogenicity from inflammation. <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> Alzheimer's hidden signs <http://p4trc.emv2.com/HS?a=ENX7CqkWrP9- 8SA9MIOatd3nGHxKLTN8GvcStGb5lw8W0bBhOG5mpqVsje_HhdBmMIEV> Presents clear evidence that the biochemical pathways thought to lead to Alzheimer's disease can precede symptoms by more than 20 years. <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> Tubulin, pure and simple <http://p4trc.emv2.com/I-IS?a=ENX7CqkWrP9- 8SA9MKJatd3nGHxKLTN8G_cStGb5lw8W0bBhOGSmpqVsje_HhdBmMIEa> The authors have developed new method of purifying tubulin from different eukaryotic sources that make it possible to conduct in vitro reconstitution experiments with much greater physiological relevance. <http://webr.emv2.com/faculty1000/F1000Monthly_images/spacer.gif> Solid trials, solid medicine chttp://p4trc.emv2.com/HS?a=ENX7CqkWrP9- 8SA9MKJatd3nGHxKLTN8GPcStGb5lw8W0bBhOG5mpqVsje_HhdBmMIEb> The ALTITUDE study (Aliskiren trial in type 2 diabetes using cardiorenal endpoints) underlines the critical importance of suitably powered trials with hard clinical endpoints in informing evidence-based treatments for patients. <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> See all new recommendations» <http://p4trc.emv2.com/HS?a=ENX7CqkWrP9- 13SA9MKJatd3nGHxKLTN8GfcStGb5lw8W0bBhOGSmpqVsje_HhdBmMIEY> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> <http://p4trc.emv2.com/HS?a=ENX7CqkWrP9- 8SA9M lOatd3nGHxKLTN8HvcStGb5lw8W0bBhOG5mpqVsje_HhdBmMIEZ> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> Open-access journals publishing reports, written by Faculty Members, on hot topics with reference to the recommended literature. chttp://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> <http://p4trc.emv2.com/HS?a=ENX7CqkWrP9- 8SA9MlUatd3nGHxKLINBH_cStGb5lw8W0bBhOG5mpqVsje_HhdBmMIEe> 2 EFTA_R1_02099224 EFTA02706139 <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> No more itch <http://p4trc.emv2.com/HS?a=ENX7CqkWrP9- 8SA9M Klatd3nGHxKLTN8HPcStGb5lw8W0b8hOG5mpqVsje_HhdBmMIEf> New preventive strategies for atopic dermatitis are made possible with the discovery that mutations in the filaggrin gene are associated with the disease. F1000 Report by Hywel C Williams <http://p4trc.emv2.com/HS?a=ENX7CqkWrP9- 8SA9MKJatd3nGHxKLTN8HfcStGb5lw8W0b8hOGSmpqVsje_HhdBmMIEc> , Joanne R Chalmers and Eric L Simpson <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> <http://p4trc.emv2.com/HS?a=ENX7CqkWrP9- 8SA9M KJatd3nGHxKLTN8EvcStGb5lw8W0bBhOG5mpqVsje_HhdBmMIEd> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> New plant species via only two mutations <http://p4trc.emv2.com/HS?a=ENX7CqkWrP9- 8SA9M Klatd3nGHxKLTN8E_cStGb5lw8W0b8hOG5mpqVsje_HhdBm MIEi> Tremendous recent advances in molecular genetics have made it clear that new plant species can evolve via two or more mutational steps, as is predicted by the Dobzhansky-Muller model. F1000 Report by Andrea L. Sweigart and John H. Willis <http://p4trc.emv2.com/HS?a=ENX7CqkWrP9- 8SA9M KJatd3nGHxKLTN8EPcStGb5lw8W0b8hOG5mpqVsje_HhdBmMIEj> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> See all new Reportso chttp://p4trc.emv2.com/HS?a=ENX7CqkWrP9- 8SA9MKJatd3nGHxKLTN8EfcStGb5lw8W0b8hOGSmpqVsje_HhdBmMIEg> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> chttp://p4trc.emv2.com/HS?a=ENX7CqkWrP9- 8SA9MKJatd3nGHxKLTN8FvcStGb5lw8W0b8hOG5mpqVsje_Hhd8mMIEh> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> ADVERTISEMENT <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> Also from Faculty of 1000 <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> <http://p4trc.emv2.com/HS?a=ENX7CqkWrP9- 8SA9M Klatd3nGHxKLTN8F_cStGbSlw8W0bBhOGSmpqVsje_HhdemMIEm> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> Open Repository chttp://p4trc.emv2.com/HS?a=ENX7CqkWrP9- 8SA9MKJatd3nGHxKLTN8FPcStGb5lw8W0b8hOG5mpqVsje_Hhd8mMIEn> for posters and slide presentations. <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> Recommended poster of the month -- Urology <http://p4trc.emv2.com/HS?a=ENX7CqkWrP9- 8SA9MlUatd3nGHxKLTN8FfcStGbSlw8W0b8hOG5mpqVsje_HhdBmMIEk> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> <http://p4trc.emv2.com/HS?a=ENX7CqkWrP9- 8SA9M KJatd3nGHxKLTN8KvcStGb5lw8W0bBhOG5mpqVsjeHhdBmMIEl> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> Sexual self-consciousness in a sample of men and women with and without sexual difficulties: an exploratory study <http://p4trc.emv2.com/HS?a=ENX7CqkWrP9- 8SA9MKJatd3nGHxKLTN8K_cStGlaSlw8W0b8hOG5mpqVsje_HhdBmMIEq> 3 EFTA_R1_02099225 EFTA02706140 Gomes A et al. <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> Presented at 11th Congress of the European Federation of Sexology (EFS) 2012, 20 - 22 Sep 2012, P33 SEXUAL DYSFUNCTIONS <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> Recommended <http://p4trc.emv2.com/HS?a=ENX7CqkWrP9- 8SA9MKJatd3nGHxKLTN8KPcStGb5lw8W0bBhOG5mpqVsje_HhdBmMIEr> by Chiara Simonelli and Roberta Rossi. <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> <http://p4trc.emv2.com/HS?a=ENX7CqkWrP9- 8SA9M KJatd3nGHxKLTN8KfcStGb5lw8W0bBhOG5mpqVsje_HhdBmMIEo> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> Browse all posters » <http://p4trc.emv2.com/HS?a=ENX7CqkWrP9- 8SA9M Klatd3nGHxKLTN8LvcStGbSlw8W0bBhOG5mpqVsje_HhdBmMIEp> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> chttp://p4trc.emv2.com/HS?a=ENX7CqkWrP9- 8SA9MlUatd3nGHxKLTN8L_cStGb5lw8W0bBhOG5mpqVsje_HhdBm MIEu> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> RESEARCH ARTICLE ALS-linked 5001in glial cells enhances ft-N-Methylamino L-Alanine (BMAA)-induced toxicity in Drosophila <http://p4trc.emv2.com/HS?a=ENX7CqkWrP9-8SA9MK.latd3nGHxKLTN8LPcStGb5lw8W0bBhOG5mpqVsje_HhdBmMIEv> (v1; ref status: Indexed, http://f1000r.es/S4BZRP <http://p4trc.emv2.com/HS?a=ENX7CqkWrP9- 8SA9M HhdBmMIEs>I hdBmMIEs> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> Published: 9 Nov 2012 <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> Rafique Islam, Emily L Kumimoto, Hong Bao, Bing Zhang. F1000 Research 1:47 <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> Free to submit only until end of 2012! All submissions received before the end of 2012 will be free of charge; after this time, we have modest Article Processing Charges <http://p4trc.emv2.com/HS?a=ENX7CqkWrP9- 8SA9M Klatd3nGHxKLTN8IvcStGb5lw8W0blihOG5mpqVsje_HhdBmMIEt> . Publish by this time next week: view our author guidelines <http://p4trc.emv2.com/HS?a=ENX7CqkWrP9- 8SA9MIOatd3nGHxKLIN8I_cStGbSlw8W0bBhOGSmpqVsje_HhdBmMIEy> and submit now to [email protected] <mailto:[email protected]> for rapid, hassle-free publication. <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> 1,515 recommendations added on F1000 Prime last month <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> chttp://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> Anesthesiology & Pain Management (100) • Cardiovascular Disorders (70) • Cell Biology (315) • Chemical Biology (120) • Critical Care & Emergency Medicine (49) • Dermatology (67) • Developmental Biology (127) • Diabetes & Endocrinology (79) • Ecology (42) • Gastroenterology & Hepatology (80) • Genomics & Genetics (226) • Hematology (61) • Immunology (115) • Infectious Diseases (85) • Microbiology (114) • Nephrology (36) • Neurological Disorders (108) • Neuroscience (128) • Oncology (109) • Opthalmology (22) • Otolaryngology (34) • Pharmacology & Drug Discovery (177) • Physiology (196) • Plant 4 EFTA_R1_02099226 EFTA02706141 Biology (43) • Psychiatry (58) • Public Health & Epidemiology (95) • Research Methodology (8) • Respiratory Disorders (86) • Rheumatology & Clinical Immunology (52) • Structural Biology (102) • Urology (49) • Women's Health (80) <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> Browse all recommendations» <http://p4trc.emv2.com/HS?a=ENX7CqkWrP9-8SA9MICIatd3nGHxKLTN8IPcStGb5lw8W0bBhOG5mpqVsje_HhdBmMIEz> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> <http://p4trc.emv2.com/HSL?lang=us&a=ENX7CqkWrP9- 8SA9MIClatd3nGHxKIJ3zyvcStGb5lw8WObBh0G5mpqVsje_HhdBmMIcL> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> chttp://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> chttp://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> Win a bag of swag! <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> <http://webr.emv2.com/faculty1000/F1000_Monthly_images/spacer.gif> <http://p4trc.emv2.com/HS?a=ENX7CqkWrP9-8SA9MlUatd3nGHxKLTN8IfcStGb5lw8W0bBhOGSmpqVsje_HhdBmMIEw> Guess the total number of recommendations that F1000Prime publishes in 2012 by tweeting @f1000 with your guess and the hashtag #2012F1000. Whoever gets the closest wins a bag of swag! 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