EFTA01059036.pdf

From: Donald Rubin To: "Jeffrey E." <jeevacation®gmail.com> Subject: Re: company valuation Date: Thu, 15 Dec 2016 16:52:20 +0000 No problem at all. I too found the "justification" bizarre -- all stories !! Keep the money for a nice dinner in Caribbean r”. See you next year Sent from DBR's iPhone On Dec 15, 2016, at 11:39 AM, Jeffrey E. [email protected]> wrote: all very very goofy. Im out sorry, no real numbers shares offering doc. just a random prof that they paid for to tell somse shmucks that this might work and if it does it will be worth somethig more than it is. . see you in Jan On Thu, Dec 15, 2016 at 11:26 AM, Donald Rubin < wrote: J, They show at the bottom of mine. But you didn't get them? D Begin forwarded message: From: Adriaan Tuiten Subject: company valuation Date: December 15, 2016 at 8:41:11 AM EST To: "Donald Rubin ( )" Dear Don, As we spoke about the valuation of the company, I herewith send you the executive summary of the valuation done by Prof. Roel Bellens of PIMS NV. This report dates from September 2015. As you will understand, this information is very confidential. In short, the report mentions a number of events, that have a positive or negative impact on the company value. There are a number of events, that are directly related to the development of Lybrido and Lybridos, such as regularity progress with the FDA and the EMA, patent extensions, etc. On the other hand there are events in the periphery of to company, that influence value of Emotional Brain. A major event was the market approval for Flibanserin/Addyi and the acquisition of Flibanserin to Valeant. The valuation of the EB shares from this valuation report was E 42.50 per share. Since 2015 there are some developments in favor of the value and some developments that might reduce the value. A very positive driver is the recent feedback by the FDA and the issued Guideline for Industry by the FDA, giving Lybrido and Lybridos explicit advice to enter phase 3 and giving clear guidelines for achieving market approval. A negative driver could be the fact that Addyi appears to fail in the market EFTA01059036  (however this was not really a surprise for EB, given the safety warnings, the low efficacy and the high user-costs, approximately 800USD/month, of the product). These disadvantages do not occur with the use of Lybrido(s), but they still might have a negative impact. We estimate, that this positive and negative factors level out, and kept the share price at E 42,50. We are checking this at the moment with Prof. Bellens. This price valuates the company at E 156mln. Recent research among 100 phase 2 pharmadeals show that dealvalues vary from USD 250 mln. (only milestones) to USD 750 mln. (only milestones). On top of that royalties varying from 12% to 22% of net sales, so we trust that this value does not overestimates the value of EB. Moreover, at an earlier stage (2013) Roel Bellens also has written a report on the possible proceeds in a deal. This revenues from upfront and milestones does not deviate much from the aforementioned revenues (worst-case between 320 and 340 million dollars; best case: between 525 and 560 million dollars). In that report he made also an estimation of the revenue that could yield by royalties over a period of about 12 years (between 2.5 billion and 6.9 billion dollars). In my humble view, these estimates are positive and I am happy with a portion thereof. Moreover, the estimation of Prof. Bellens is based on pre- and postmenopausal women. We will do out phase 3 research only in premenopausal women which will reduce the royalty revenues somewhat (however pharmaceutical companies assume — I think - that there will be off-label use by the postmenopausal women). I hope you can use this information to attract investors, I enclosed the reports in order to check the summary I made of the valuation. Again, the valuation reports are extremely confidential, so do not share them with others. Best Adriaan please note The information contained in this communication is confidential, may be attorney-client privileged, may constitute inside information, and is intended only for the use of the addressee. It is the property of JEE Unauthorized use, disclosure or copying of this EFTA01059037 communication or any part thereof is strictly prohibited and may be unlawful. If you have received this communication in error, please notify us immediately by return e-mail or by e-mail to [email protected], and destroy this communication and all copies thereof, including all attachments. copyright -all rights reserved EFTA01059038