EFTA01197927.pdf

Biosketch Judith Miklossy MD, PhD, DSc FRCP (H) in Neurology, Psychiatry & Psychotherapy FRCP (CH) in Neuropathology Prevention Alzheimer International Foundation International Alzheimer Research Center Martigny-Croix CP 16 1921 Switzerland Tel: URLs: www.miklossy.ch www.preventionalzheimer.org Centre Medical Vigimed Consultation de Neurologie Rue du Leman 12B 1920 Martigny June, 2014 Education/ Training 1971 MD, University Medical School of Debrecen, Hungary with EU & AELE conformity certificate) 1976 Board certified in Neurology, University of Debrecen, National Board of Specialization, Hungary with EU & AELE conformity certificate 1982 Board certified in Psychiatry and Psychotherapy, National Institute Neurology & Psychiatry, Budapest, National Board of Specialization, Hungary with EU & AELE conformity certificate. 1995 Maitre d'Enseignement et de Recherche (MER), CHUV University of Lausanne 1995 PD (Dr. habil, DSc), University Institute of Neuropathology, CHUV & University of Lausanne, Switzerland 2001-2004 Invited scientist Molecular biology, Temple University, Philadelphia, P.A., U.S.A. 2005 PhD, Neurobiology, University of Debrecen, Hungary 2004-2007 Invited scientist Neurological research, University of British Columbia, Vancouver, Canada, Head of neuropathology in the Kinsmen Laboratory of Neurological Research, The University of British Columbia 2011 Board certified in Neuropathology (FMH), Federation of Swiss Physicians, Switzerland Positions and employments 1967-1971 Resident as student, Institute of Physiology, University of Debrecen, Hungary 1971-1976 Resident, Chief-Resident, staff member, neurologist, Institute of Neurology, Psychiatry and Neurosurgery, University of Debrecen (DOTE), Hungary 1977-1982 Staff member - Instructor, psychiatrist, National Institute of Neurology and Psychiatry, Budapest, Hungary EFTA01197927 1982-1995 Staff member — Instructor, neuropathologist, University Medical School of Lausanne, Switzerland 1995-2005 Medecin associe, MER and PD, equivalent of Assistant Professor, University Institute of Pathology, CHUV, University Medical School of Lausanne, Switzerland 2001-2004 Visiting scientist, neuroscience research in molecular biology, Participation in the introduction of Alzheimer's research, Center for NeuroVirology, Temple University, Philadelphia, PA, USA 2004 — 2007 Visiting scientist, Kinsmen Laboratory of Neurological Research, Head of Neuropathology laboratory in the Kinsmen Laboratory of Neurological Sciences (Director. Prof. Patrick L. McGeer) The British Columbia University, Vancouver, BC, Canada 2010 - President, then Director of the Prevention Alzheimer International Foundation, Martigny- Combe, Switzerland 2012- Director of the International Alzheimer Research Center, Martigny-Combe, Switzerland. Neurology consultation on memory and Lyme disease in the Medical Center of Vigimed, Martigny, Switzerland Awards and Honors 1971 - 2nd National prize and Is, university prize of distinction for MD thesis, University Medical School of Debrecen, Hungary 1975 - Specialty board Exam and Certificate in Neurology Institute of Neurology, Psychiatry and Neurosurgery, Hungary, with distinction excellent (5/5) 1976 Best young researcher award, Institute of Neurology, Psychiatry and Neurosurgery, DOTE, University of Debrecen, Hungary 1980 Specialty board Exam and Certificate in Psychiatry and Psychotherapy, National Institute of Neurology and Psychiatry, Budapest, with distinction excellent (5/5) 1995 PD and MER degrees — Assistant Professor, University Institute of Pathology, Lausanne, Switzerland 2005 - PhD thesis (Summa cum laude), University Medical School of Debrecen, Academy of Sciences, Hungary - Director and supervisor Prof PL McGeer, The University of British Columbia, Vancouver, BC, Canada Other Experiences and Professional Memberships 1971- 2005 Postgraduate and undergraduate teaching of Neurology, Psychiatry and Neuropathology 1995 — 2005 Head of research group "Neurodegeneration", University Institute of Pathology, University Medical School of Lausanne, University of Lausanne (CHUV, UNIL), Switzerland 2004-2007 Head of Neuropathology laboratory, Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, Canada 1996- On the Board of Director Physicians of Swiss Hospitals, Switzerland 2005- On the Board of Directors then on the Scientific Advisory Board of the Canadian Lyme Foundation 2008- On the Advisory Scientific Board of the Deutsche Borreliose Gesellschaft 2012 - On the Scientific Advisory Scientific Board of Lyme Research Allianz 2005- 2008 Associate editor of the Journal of Alzheimer Disease (JAD), from 2008 of the International Journal of Alzheimer Disease, and from 2011 of the Acta Neuropathologica Communications. Member of several scientific organizations, including Association of Swiss Neuropathologists, Association of Swiss Neurologists, Society of Swiss Pathologists, Society of Neuroscience, Alzheimer's EFTA01197928 Association, International Society to Advance Alzheimer Research and Treatment (ISTAART), International Brain Organization (IBRO), Societe Academique Vaudoise, International Society of Neurovirology, Swiss Medical Association (FMH). 2014- Member of the foreign body of the Hungarian Academy of Sciences Research interest Our research interests include the pathogenesis of Alzheimer's disease (AD) and other neurodegenerative and chronic inflammatory disorders. From 1993 my research focused on the role of bacteria, particularly of spirochetes, in persistent chronic infection, inflammation and amyloidogenesis in AD. A century ago, Fischer (1907) has been suggested and Alzheimer and his colleagues have been cited his view and discussed the possibility that microorganisms might play a role in senile plaque formation. Additionally, there is an example in the history of medicine that chronic bacterial infection, namely chronic spirochetal infection (Treponema pallidum) can cause slowly progressive dementia and reproduce the pathological and biological hallmarks of AD. Increasing amount of recent data indicate, as we have suggested in 1993, that several types of spirochetes, including Borrelia burgdorferi and periodontal pathogen spirochetes are involved in the pathogenesis of AD. Recently, reviewing all data available in the literature a statistically strongly significant association, with a high risk factor was found between spirochetes and AD, fulfilling Hill's criteria in favor of a causal relationship. Exposure of human and mammalian primary CNS cells and organotypic cultures to spirochetes, showed that similarly to Treponema pallidum, Borrelia burgdorferi reproduces the pathological and biological hallmarks of AD (increased ApPP, Ap and (p)tau levels). We have identified the first susceptibility gene, the Islet-brain-1 (IBI, encoded by MAPK8IP1), for type 2 diabetes and reported first the presence of local infection and inflammation associated with affected pancreatic islets in type-2 diabetes. Bacterial peptidoglycan, LPS and several bacteria, including spirochetes, Chlamydia pneumoniae and Helfrobacter pylori were found to be associated with amyloid deposition in the affected Langerhans islets. Now from three decades we are involved in Lyme disease research. We have published the first pathological confirmation of the meningovascular form of chronic or late Lyme neuroborreliosis leading to cerebral vascular infarcts. Together with other authors we contributed to the pathological confirmation of the other major form of chronic Lyme neuroborreliosis, which is identical to the atrophic form of general paresis associated with slowly progressive dementia caused by Treponema pallidum in syphilis. We presented evidences on the direct involvement of Borrelia burgdorferi in the major tertiary forms of chronic Lyme neuroborreliosis. On invitation we contributed with a chapter on the pathology and biology of dementia in syphilis and Lyme disease in the prestigious Handbook of Clinical Neurology. We have published observations on the presence of various pleomorphic forms, including the more resistant cystic, granular and L forms of Borrelia burgdorferi, in pure Borrelia cultures in infected cell cultures and in brains of demented patients with clinically, serologically and pathologically confirmed Lyme neuroborreliosis. We have also shown that Borrelia burgdorferi spirochetes cultivated from the brains of these patients are virulent and invade neuronal and glial cells and cause apoptosis. Recently, reviewing descriptions and illustrations available on the pathology of Lyme neuroborreliosis from the past 30 years, we reported that the major late or chronic forms of neurosyphilis were EFTA01197929 pathologically confirmed in Lyme disease as well and Borrelia burgdorferi was cultivated from tertiary lesions by various authors. These observations definitely indicate that chronic Lyme disease exists and Borrelia bzirgdotferi, similarly to Treponema pallidum plays a direct role in the pathogenesis of the tertiary manifestations of chronic/late Lyme disease. Publications Number of publications (articles, book chapters and published abstracts: 238) Published articles and book chapters: 113 (105 per reviewed) Mean impact factor: 5.02 Some selected publications I. Miklossy J, Kuntzer T, Bogousslaysky J, Regli F, Janzer RC. Meningovascular form of neuroborreliosis: Similarities between neuropathological findings in a case of Lyme disease and those occurring in tertiary neurosyphilis. Acta Neuropathol 1990;80:568-572. 2. Miklossy J. Alzheimer's disease - A spirochetosis? Neuroreport. 1993; 4:841-848 3. Miklossy J, Taddei K, Martins R, Escher G, ICrafisik R, Pillevuit O, Lepori D, Campiche M. Alzheimer disease: curly fibers and tangles in organs other than brain. J Neuropathol Exp Neurol. 1999;58:803-814. 4. Waeber G, Delplanque J, Bonny C, Mooser V, Steinmann M, Widmann C, Maillard A, Miklossy J, Dina C, H Hani E, Vionnet N, Nicod P, Boutin P, Froguel P. The gene MAPK8IP1, encoding islet- brain-I, is a candidate for type 2 diabetes. Nature Genetics, 2000; 24: 291-295. Press release 5. Mooser V, Helbecque N, Miklossy J, Marcovina SM, Nicod P, Amouyel Ph. Interactions between Apolipoprotein E and Apolipoprotein(a) in patients with Late-Onset Alzheimer disease. Ann Intern Med 2000;132:533-537. 6. Miklossy J, Khalili K, Gem L, Ericson RL, Darekar P, Bolle L, Hurlimann J, Paster BJ. Borrelia burgdorferi persists in the brain in chronic Lyme neuroborreliosis and may be associated with Alzheimer disease. J Alzheimer's Dissease 2004, 6:1-11. 7. Guo J, Arai T, Miklossy J, and McGeer PL. A-beta and tau form soluble complexes that may promote self aggregation of both into the insoluble forms observed in Alzheimer disease. P.N.A.S. Proc Natl Acad Sci USA. 2006;103:1953-8. 8. Miklossy J, Kis A, Radenovic A, Miller L, Forro L, Martins R, Reiss K, Darbinian N, Darekar P, Mihaly L, Khalili K. Beta-amyloid deposition and Alzheimer's type changes induced by Borrelia spirochetes. Neurobiol Aging 2006; 27:228-236. 9. Miklossy J. Biology and neuropathology of dementia in syphilis and Lyme disease. In: Handbook of Clinical Neurology, Dementias, Vol 89 (3id series), Eds: C Duyckaerts, I Litvan, Elsevier, (Edinburgh, London), 2008, Volume 89, Chapter 72, pp. 825-844. 10. Miklossy J, Kasas S, Zurn A, McCall S, Yu S, McGeer PL. Persisting atypical and cystic forms of Borrelia burgdorferi and local inflammation in Lyme neuroborreliosis. J. Neuroinflammation, 2008,5:40. II. Miklossy J. Alzheimer's disease - a neurospirochetosis. Analysis of the evidence following Koch's and Hill's criteria. J Neuroinflammation. 2011; 8:90, highly cited 12. Miklossy J. Emerging roles of pathogens in Alzheimer disease. Expert Rev Mol Med. 2011; 13: e30. EFTA01197930