EFTA02353720.pdf

From: Peter Attia Sent: Monday, June 22, 2015 4:50 PM To: Jeffrey E. Subject: RE: JASON With the caveat that it's a year old and my thinking has evolved... BTW—I thought of another analogy. Are you familiar with what Bruce Lee did for fighting/martial arts? The development of Jeet Kune Do (JKDP From: jeffrey E. [mailto:[email protected]] Sent: Monday, June 22, 2015 7:24 AM To: Peter Attia Subject: Re: JASON I sent larry summers your manifesto this morning. On Mon, Jun 22, 2015 at 10:22 AM, Peter Atti wrote: Only 24 hours. Back again July 6-9 and 12-14. We can review your labs then, assuming you're in town one of those trips. White board needed. From: jeffrey E. [mailto:[email protected] <mailto:[email protected]> Sent: Monday, June 22, 2015 7:19 AM To: Peter Attia Subject: Re: JASON sorry will miss you this trp how long are you staying? On Mon, Jun 22, 2015 at 10:18 AM, Peter Attia wrote: About to run out the door. Later today? I redeye to NY tonight (not good for longevity). EFTA_R1_01334506 EFTA02353720 From: Jeffrey E. [mailto:[email protected] <mailto:[email protected]> ] Sent: Monday, June 22, 2015 7:17 AM To: Peter Attia Subject: Re: JASON . i have 20 minutes now. lets chat if you are free On Mon, Jun 22, 2015 at 10:14 AM, Peter Atti wrote: Think Bruce Lee: extract what is useful, disregard what is useless. I think you're taking the examples too literally. We can do much better than the long lived societies today because we have more than they do on most fonts—drugs, hormones, greater sense of purpose —but they have a few things we didn't and that's what we need to "extract" in insight. Chief among them is what they ate. The problem I'm trying to solve, as unemotionally and undogmatically as possible, is how to hack all of the variables to maximize lifespan in the constraints of maximum healthspan. From: Jeffrey E. [mailto:[email protected] <mailto:[email protected]> ] Sent: Monday, June 22, 2015 4:35 AM To: Peter Attia Subject: Re: JASON thanks, i had to laugh, your examples of long living socieites appears to bolster my arguement that it might be inversely proportional to cognitive skills. . those tribes stand out from the rest of the world as the most backward. maybe ignorance is not only bliss but you live longer in it. its not your darkened room of 150 years example , but its pretty close 2 EFTA_R1_01334507 EFTA02353721 On Mon, Jun 22, 2015 at 1:41 AM, Peter Attia MIIIMI IIMINIMm wrote: Here is manifesto. Substrate for long discussion. I even open with a quote from PT. I wrote this last summer, so it's a bit dated relative to my recent thinking. Re: sleep, most evidence says 7.5 to 8.5 hours, even as adults. From: jeffrey E. [mailto:[email protected] <mailto:[email protected]> ] Sent: Sunday, June 21, 2015 10:24 PM To: Peter Attia Subject: Re: JASON no you did not. Im not sure how to titrate what to tweak. . if a baby sleeps 12 hours a day. and an adolexcent 8. . if an older person sleeps 6 is that ? natural" ? is natural a path to gene deterimined death. I think eating your ancestors diet is probably the worst thing. given that paradigm On Mon, Jun 22, 2015 at 1:00 AM, Peter Attia wrote: You and I are 100% aligned on that. Wait till I fill you in on my pharmaco strategy... Once we see your results, the fun starts. That said, the greatest first line medicine—as corny as this sounds—is what you eat. My goal is to combine the best evidence of diet/sleep/exercise/drugs/hormones into a super longevity package. Did I ever send you my manifesto? From: jeffrey E. [mailto:[email protected] <mailto:[email protected]> ] Sent: Sunday, June 21, 2015 9:42 PM To: Peter Attia Subject: Re: JASON conjecture - natural . is good when you are young. natural is bad when you are old. . proecting yourself FROM nature is the essence of longevity. your metformin is probably right on. .. you ve convinced me . I want to look to my ancestors only before the age of 40. after i want to look to modern science. On Sun, Jun 21, 2015 at 8:49 PM, Peter Attia wrote: 3 EFTA_R1_01334508 EFTA02353722 Agree that the data of the 50s mean little. I'm talking about a different problem, which is more social/behavioral than scientific. Understanding the nuances of WWI, II probably add little to understanding ISIL, but that's the "wrong" history. If ISIL is the focus, at least IMO, understanding FDR's relationship with Abdulaziz Ibn Saud does help, even though it took place 80 years ago. Our work in cancer and AD will be different, but in obesity there is likely no addressing the problem without some appreciation for how this mess was created. From: Jeffrey E. [mailto:[email protected] <mailto:[email protected]> Sent: Sunday, June 21, 2015 3:14 PM To: Peter Attia Subject: Re: JASON not at all, reading about world war one or two, or vietnam , gives me no insight into isil.. boko harem .etc. I listen to you becuse the science says x using tools of today any work using tools of yesterday, seems a little odd. germs before a microscope. etc. no data in the 50s worth noting. On Sun, Jun 21, 2015 at 5:47 PM, Peter Atti wrote: This isn't a diet book, in which case that info would be irrelevant. It's a book making the most provocative case ever in nutrition: our fundamental understanding obesity and disease might be wrong entirely. To make that case, GT needs to explain the history of how we got there. Can I understand WWII without understanding WWI? Maybe, but not nearly as well. Can a president make a rationale decision about invading Iraq without understanding the history of the tribes that make it up? Apparently not. Read this through the lens of "How can I take Peter seriously when he says X or Y about nutrition, when it so clearly flies in the face of my friends at NIH, CDC, FDA, ARA, ADA, ...?" From: Jeffrey E. [mailto:[email protected] <mailto:[email protected]> Sent: Sunday, June 21, 2015 2:03 PM To: Peter Attia 4 EFTA_R1_01334509 EFTA02353723 Subject: Re: JASON spent two hours reading good bad calories. I think it suffers from too much history. studies in the 50.s who cares. more for anthropologyl On Sun, Jun 21, 2015 at 3:21 PM, Peter Attia wrote: Bad ass: https://en.wikipedia.orewiki/JASON_(advisory_group) From: jeffrey E. [mailto:[email protected] <mailto:[email protected]> Sent: Sunday, June 21, 2015 12:02 PM To: Peter Attia Subject: Re: JASON what are they? On Sun, Jun 21, 2015 at 1:07 PM, Peter Attia wrote: Have you ever been to one of their meetings? Confidentiality Notice: This e-mail is confidential and intended only for the recipients listed above. If you have received this e-mail in error, please delete it immediately and inform the sender of the error or contact [email protected] <mailto:[email protected]> 5 EFTA_R1_01334510 EFTA02353724  please note The information contained in this communication is confidential, may be attorney-client privileged, may constitute inside information, and is intended only for the use of the addressee. It is the property of JEE Unauthorized use, disclosure or copying of this communication or any part thereof is strictly prohibited and may be unlawful. If you have received this communication in error, please notify us immediately by return e-mail or by e-mail to [email protected] <mailto:[email protected]> , and destroy this communication and all copies thereof, including all attachments. copyright -all rights reserved please note The information contained in this communication is confidential, may be attorney-client privileged, may constitute inside information, and is intended only for the use of the addressee. It is the property of JEE Unauthorized use, disclosure or copying of this communication or any part thereof is strictly prohibited and may be unlawful. If you have received this communication in error, please notify us immediately by return e-mail or by e-mail to [email protected] <mailto:[email protected]> , and destroy this communication and all copies thereof, including all attachments. copyright -all rights reserved please note The information contained in this communication is confidential, may be attorney-client privileged, may constitute inside information, and is intended only for the use of the addressee. It is the property of JEE Unauthorized use, disclosure or copying of this communication or any part thereof is strictly prohibited and may be unlawful. If you have received this communication in error, please notify us immediately by return e-mail or by e-mail to [email protected] <mailto:[email protected]> , and destroy this communication and all copies thereof, including all attachments. copyright -all rights reserved please note The information contained in this communication is confidential, may be attorney-client privileged, may constitute inside information, and is intended only for the use of the addressee. It is the property of JEE Unauthorized use, disclosure or copying of this communication or any part thereof is strictly prohibited and may be unlawful. If you have received this communication in error, please notify us immediately by return e-mail or by e-mail to [email protected] <mailto:[email protected]> , and destroy this communication and all copies thereof, including all attachments. copyright -all rights reserved 6 EFTA_R1_01334511 EFTA02353725  please note The information contained in this communication is confidential, may be attorney-client privileged, may constitute inside information, and is intended only for the use of the addressee. It is the property of JEE Unauthorized use, disclosure or copying of this communication or any part thereof is strictly prohibited and may be unlawful. If you have received this communication in error, please notify us immediately by return e-mail or by e-mail to [email protected] <mailto:[email protected]> , and destroy this communication and all copies thereof, including all attachments. copyright -all rights reserved please note The information contained in this communication is confidential, may be attorney-client privileged, may constitute inside information, and is intended only for the use of the addressee. It is the property of JEE Unauthorized use, disclosure or copying of this communication or any part thereof is strictly prohibited and may be unlawful. If you have received this communication in error, please notify us immediately by return e-mail or by e-mail to [email protected] <mailto:[email protected]> , and destroy this communication and all copies thereof, including all attachments. copyright -all rights reserved please note The information contained in this communication is confidential, may be attorney-client privileged, may constitute inside information, and is intended only for the use of the addressee. It is the property of JEE Unauthorized use, disclosure or copying of this communication or any part thereof is strictly prohibited and may be unlawful. If you have received this communication in error, please notify us immediately by return e-mail or by e-mail to [email protected] <mailto:[email protected]> , and destroy this communication and all copies thereof, including all attachments. copyright -all rights reserved please note The information contained in this communication is confidential, may be attorney-client privileged, may constitute inside information, and is intended only for the use of the addressee. It is the property of JEE Unauthorized use, 7 EFTA_R1_01334512 EFTA02353726 disclosure or copying of this communication or any part thereof is strictly prohibited and may be unlawful. If you have received this communication in error, please notify us immediately by return e-mail or by e-mail to [email protected] <mailto:[email protected]> , and destroy this communication and all copies thereof, including all attachments. copyright -all rights reserved please note The information contained in this communication is confidential, may be attorney-client privileged, may constitute inside information, and is intended only for the use of the addressee. It is the property of JEE Unauthorized use, disclosure or copying of this communication or any part thereof is strictly prohibited and may be unlawful. If you have received this communication in error, please notify us immediately by return e-mail or by e-mail to [email protected] <mailto:[email protected]> , and destroy this communication and all copies thereof, including all attachments. copyright -all rights reserved 8 EFTA_R1_01334513 EFTA02353727