EFTA01787545.pdf

From: Donald Rubin Sent: Wednesday, Decem er , 1 : PM To: jeffrey E. Subject: Re: Placebo effects, EB, etc. Super. On =ec 7, 2016, at 12:47 PM, jeffrey E. <[email protected]> wrote: i might come up again, will know tomrow. let you =now. On Wed, Dec 7, 2016 at 1:47 PM, Donald Rubin > wrote: Think =o. Where will you be? On Dec =, 2016, at 12:25 PM, jeffrey E. <[email protected]> wrote: ar you around on the =eekend in cambridge.? On Wed, Dec 7, 2016 at 1:10 PM, =onald Rubin cwrote: OK. I'll get back to you after = make contact with Adriaan again, and my plans settle a bit. On Dec 7, 2016, at 10:38 AM, jeffrey E. <[email protected]> wrote: three way skype for =. and yes 1 face to face On Wed, =ec 7, 2016 at 11:37 AM, Donald Rubin rote: Different ways to follow up. 1. The next time =hat we're in the same town, we could talk about the statistical =deas underlying ways to disentangle placebo effects from biological =ffects of drugs and why that's important for FDA approvals and =or prescripts in the docs office — different answers, I =hink. EFTA_R1_00111000 EFTA01787545  2. = can send some recent things on the topic of placebo response, which =re still not that wonderfully written. 3. If interested in exploring =nvesting in EB, I can put you in touch with Adriaan, who lives in =msterdam. Are =ny of these appealing? I prefer 1 to 2. I think a face to =ace version of 3 could be arranged either here or there. let me =now. On Dec 7, 2016, at 9:35 AM, jeffrey E. <[email protected]> wrote: I'm always interested in unique idea On =ed, Dec 7, 2016 at 10:12 AM Donald Rubin wrote: Hello Jeffrey, I'm glad that Martin has put us in touch for a =ouple of reasons. First, I think we have some mutual interests =oncerning the complications of doing experiments with humans, rather =han plants or animals or tires. One complication is noncompliance =ith the assigned treatment, which we briefly discussed at the dinner, =ut the more interesting one is the placebo effect, which can be =igantic, for example in "viagra" type studies, which we =idn't get around to discussing except indirectly in the context =f the Emotional Brain (EB) female viagra issue. More generally, this is related to FDA standards for =pproving drugs. A slight aside: in January I'm one of =hree people getting honorary degrees from the Medical Faculty of the =niversity of Uppsala in Sweden, where one of the others is Robert =aliff, the current Commissioner of the FDA (the other is Marcia McNutt, =he current President of the National Academy of Sciences), so I should =et the chance to bend his ear at various meals (a former commissioner =E24$ under Bush II — was a partial PhD student of mine when =e was getting his MD at Harvard and his PhD in Econ at MIT, and remains = good friend: Mark McClellen, who is interested in this stuff and =emains quite influential in DC, I think). But the reason for rambling about the FDA and placebo =ffects is the following. This morning I just had an exchange of =mails with the CEO of EB, whom I've known and worked with for =bout three years, Adriaan Tuiten. He wrote that FDA has agreed =ith EB's proposal for more trials, and the EB board of =irectors just approved the issuance of about 12 million Euros in stock =o pay for these trials. Adriaan thinks that they may have enough =onnections now, but would you be interested in participating? I =lready have some stock, which I earned though consulting. I =hink EB is interesting but still needs more wisdom when it comes to =heir statistics (I've been to FDA with them two or three times, =nd I think they still need help with some of their ideas e.g., using =NPs). If interested in tossing some money their way, let me =now. In any case, I very much enjoyed our last conversations, and = look forward to seeing you again, either in Cambridge or in NYC, which ='II probably get to in the next couple of weeks. Best wishes, Don 2 EFTA_R1_00111001 EFTA01787546  Donald B. Rubin John L. Loeb Professor of Statistics Department of Statistics, Harvard University On Dec 2, 2016, at 9:41 AM, jeffrey E. <[email protected]> =rote: great On Fri, Dec 2, 2016 at 9:40 AM, Donald Rubin < wrote: Great, thanks Martin. =ometime when I get to NYC, which I often do to visit Columbia =onnections, I'd like to be in touch, and give Jeffery more =ectures in statistics — I think he has some potential! Also, Martin, should we try to =ouch base on Monday? The rest of the week is pretty much shot for =e with visitors. Best, Don 3 EFTA_R1_00111002 EFTA01787547 > On Dec 2, 2016, at 9:32 =M, Nowak, Martin A. wrote: > Don , Jeffrey > I would like to put you =n direct email contact. > also cc Lesley. please note 4 EFTA_R1_00111003 EFTA01787548  The information contained in this communication is confidential, may be attorney-client privileged, may constitute inside information, and is intended only for the use of the addressee. It is the property of JEE Unauthorized use, disclosure or copying of this communication or any part thereof is strictly prohibited and may be unlawful. If you have received this communication in error, please notify us immediately by return e-mail or by e-mail to [email protected], and destroy this communication and all copies thereof, including all attachments. copyright -all rights reserved please note The information contained in this =ommunication is confidential, may be attorney-client =rivileged, may constitute inside information, and is =ntended only for the use of the addressee. It is the =roperty of JEE Unauthorized use, disclosure =r copying of this communication or any part thereof is =trictly prohibited and may be unlawful. If you have =eceived this communication in error, please notify us =mmediately by return e-mail or by e-mail to [email protected], and destroy this =ommunication and all copies thereof, including all =ttachments. copyright -all rights reserved please note The information contained in this =ommunication is confidential, may be attorney-client =rivileged, may 5 EFTA_R1_00111004 EFTA01787549  constitute inside information, and is =ntended only for the use of the addressee. It is the =roperty of JEE Unauthorized use, disclosure =r copying of this communication or any part thereof is =trictly prohibited and may be unlawful. If you have =eceived this communication in error, please notify us =mmediately by return e-mail or by e-mail to [email protected], and destroy this =ommunication and all copies thereof, including all =ttachments. copyright -all rights reserved please note The information contained in this =ommunication is confidential, may be attorney-client =rivileged, may constitute inside information, and is =ntended only for the use of the addressee. It is the =roperty of JEE Unauthorized use, disclosure =r copying of this communication or any part thereof is =trictly prohibited and may be unlawful. If you have =eceived this communication in error, please notify us =mmediately by return e-mail or by e-mail to [email protected], and destroy this =ommunication and all copies thereof, including all =ttachments. copyright -all rights reserved 6 EFTA_R1_00111005 EFTA01787550