EFTA00991356.pdf

From: "jeffrey E." <[email protected]> To: Lesley Groff Subject: Re: Jeffrey Epstein Date: Thu, 05 Jun 2014 23:01:59 +0000 weekend or monday afternoon On Thu, Jun 5, 2014 at 3:31 PM, Lesley Groff < wrote: Would you like to schedule a call with Joe? Tomorrow or over the weekend works for him. (M) 774-3346 Sent from my iPhone Begin forwarded message: From: Joseph Thakuria < Date: June 5, 2014, 4:36:50 PM EDT To: Lesley Groff Cc: Richard Kahn Subject: Re: Jeffrey Epstein OK, let's set up the call for the other topics (a and b above). We wouldn't just do his bioinformatic analyses and not the rest. Ie, the bioinfo platform will cost the same for 1 person vs 100 or more once the system is purchased. But I'll look into other funding for this. Obviously (and hopefully this was clear), Jeffrey's enrollment in the study has absolutely no bearing on whether he helps fund the bioinfo or not. I wouldn't do that to him. He's in regardless. As we look to fund this piece, it just seemed worth asking. Thx, Joe On Thu, Jun 5, 2014 at 4:13 PM, Lesley Groff < wrote: Hi Joe...Jeffrey says he wants to do his first and then after this, he would be happy to fund the others... On Jun 5, 2014, at 3:46 PM, Joseph Thakuria < > wrote: Thanks - this is research so nothing can be 100% certain ,but, to my knowledge, our study will have greater NGS data privacy than any other similar medical genomics research effort. Afterwards, if Jeffrey still wanted to share his data through the PGP or other efforts, we could help facilitate that. Best, EFTA00991356 Joe On Thu, Jun 5, 2014 at 3:40 PM, Lesley Groff > wrote: Hi Joe! What fabulous news! I will pass this along to Jeffrey and Rich our accountant) Hopefully Jeffrey can call you very soon-.! I'll see if I can get a possible day/time.. On Jun 5, 2014, at 3:34 PM, Joseph Thakuria < > wrote: Sorry for the delayed response. We just got word from the IRB and we're finally ready to push forward with the YPO study. I wanted to discuss a couple things with Jeffrey by phone at his convenience including: a) getting a whole genome through Illumina puts him a little bit outside of the workflow pipeline for the YPO project. Ie, those participants are paying $1000 each and will be getting their exomes sequenced through Ambry, a thumbnail drive of their compressed genomic data, and an annotated report of 56 ACMG gene hits. I think it's worth getting him into this queue as well so he goes through the same pipeline as the YPO folks and others in our study. Last time I discussed with him he definitely wanted a whole genomes through Illumina for —$11,000 (which is still fine) but would he be interested in also getting the $1000 exome to also go through the normal pipeline? Although the exome data should be redundant with the whole genome data, I think it's worth it for the thumbnail drive and the ACMG gene summary. We'll also be able to check for concordance between the 2 datasets. b) Jeffrey has samples (including fibroblast cell culture from his skin biopsy) at HMS. Do I have his permission to request these samples from the PGP for inclusion in the YPO study? (The samples can be used for both studies if he wishes.) Our YPO study may need a self-collected saliva sample for which I can mail him a kit. So, I wanted to discuss these sample issues with him as well. c) Lastly, we actually still need some bioinformatic and genetic counselor support for the YPO study - not just for his sample but all of our 80 plus YPO study subjects (from the Austin chapter). As I mentioned, all 80+ have already paid $1000 each for the sequencing but we still need to cover bioinformatics and a part-time GC for all particpants. In the past, months ago now do to the IRB delay, Jeffrey was generous enough to offer to pay for sequencing of YPO members. Since that's already covered, I'm wondering if he would consider donating financial support for bioinformatic infrastructure for this study. I'm available to discuss later this evening. Tomorrow and this weekend are also relatively open for a brief call. My cell is 917-774-3346. Thanks in advance for passing on this message. We're excited to finally be moving forward with our innovative study. Best, Joe On Thu, May 29, 2014 at 1:29 PM, Lesley Groff <1 > wrote: EFTA00991357  Hello Joe! Hope you are well and enjoyed the Memorial Day weekend...Jeffrey is asking if you have been able to submit his sample as of yet? Can you let me know where we stand? Thanks, please note The information contained in this communication is confidential, may be attorney-client privileged, may constitute inside information, and is intended only for the use of the addressee. 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