EFTA00775344.pdf

From: F1000 Biology Update To: Jeff Epstein cjeeproject®yahoo.com> Subject: Is sitting down bad for you? Do your mice arrive with hidden baggage? And much more! Date: Mon, 01 Jun 2009 16:06:35 +0000 View in your defult web browser. 01-Jun-2009 Search F1000 Biology Submit Please note: The search function will not work for all email clients. Click here to search F1000 Biology. Vac giFaculty of 1000 Biology ulty Faculty of 1000 Biology Major Advances. Expert Opinions. In this issue... F1000 Biology Reports Editor's choice: Is sitting down bad for you? Take advantage of limited full access to some of F1000 Biology's most popular recent evaluations Broad impact: New co-catalytic role found for scaffolding protein Ste5 in yeast Is your Institution the Best Place to Work in Academia? Hidden Jewel: "Do your mice arrive with hidden baggage?" F1000 on Twitter, Facebook and LinkedIn! Recommend F1000 to your librarian! Faculty of 1000 Biology Posters F1000 Biology Reports See the latest issue of F 1000 Biology Reports which contains 8 new articles, including one entitled Describing protein r ',[F1000 Reports Logo] conformational ensembles: beyond static snapshots by Structural Biology Section Head George N Philips. If you would like to be alerted about the most recently published F1000 Reports each month, please email and put "F1000 Biology Reports" in the subject heading. hack to Ion Editor's choice: Is sitting down bad for you? EFTA00775344 After years of health campaigns, we all know that lack of exercise is bad for our health, and many of us take time out of our day to do some physical activity. The authors of this paper, evaluated by Craig Harms of the Physiology. Faculty, with Sara K Rosenkranz, suggest that, regardless of exercise levels, the amount of time spent sitting down each day has a detrimental effect on our health. Dr Harms writes "The interesting findings from this study are that there appears to be a dose-response relationship between sitting time and mortality from all causes and CVD, and that this association is independent of whether or not the person is physically active outside of the sedentary time." Dr Harms ex lains "It appears that it is not just a lack of exercise which increases the risk of mortality, but the quantity of sitting time." He also goes on to say "The authors propose that future physical activity guidelines may need to include recommendations which address daily sitting time. They present strong evidence for such future recommendations." Read the comments in full hack to too Take advantage of limited full access to some of FI000 Biology's most popular recent evaluations In this landmark paper, the Cross group identifies histone variants that mark RNA polymerase II promoters and terminators, and maps all such promoters in the genome — including many previously unidentified ones where there is no direction change... MORE Selected by 'Christine Clayton (University of Heidelberg, Germany) Four histone variants mark the boundaries of pAycistronic transcription units in Trypanosoma brucei. .t,,,,, 9.0 Siegel TN et al. Genes Dev 2009 May 123(9):1063-76 This paper represents a significant advance in the way that induced pluripotent stem (iPS) cells are generated by demonstrating that these cells can be made by the delivery of a set of recombinant proteins rather than by gene transfection...MORE Selected by 'William H Colledge (University of Cambridge, UK) ige Read Generation of induced pluripotent stem cells using recombinant proteins. FI000 Factor 6.4 Zhou H et al. Cell Stern Cell 2009 May 8 4(5):381-4 Cebrian and colleagues present the first empirical demonstration that the nutritional quality of primary producers controls the trophic structure of ecosystems...MORE Selected b 'Kai Chan (University of British Columbia, Canada) with Rebecca Martone Producer nutritional quality controls ecosystem trophic structure. F1000 Factor 6.0 Cebrian J et al. PLoS ONE 2009 4(3):e4929 EFTA00775345 The results in this manuscript help to nullify recent doubts concerning the validity of the lipid raft concept by directly demonstrating that such segregation exists following receptor occupancy...MORE Selected by IE. Charles Snow (University of Kentucky Medical Center, USA) Accumulation of raft lipids in T-cell plasma membrane domains engaged in TCR signalling. F1000 Factor 6.0 I Zech T et al. EMBO J 2009 Mar 4 28(5):466-76 Placebos provide more effective pain relief to people who are reward-seekers than to individuals with different personalities, according to this intriguing study...MORE Selected by 'Kent Berridge (University of Michigan, USA) The anatomy of the mesolimbic reward system: a link between LWI personality and the placebo analgesic response. 11111 i ).0 Schweinhardt Petal..! Neurosci 2009 Apr 15 29(15):4882-7 hack to too ot., Broad Impact: New co-catalytic role found for scaffolding protein SteS in yeast The scaffold protein Ste5 has long been known to facilitate the directional flow of mitogen- activated protein kinase (MAPK) intracellular pathways in yeast by recruiting signalling molecules. However, in this recent 'Must Read' article highlighted on Faculty of 1000 the authors identify an additional catalytic role. Moosa Mohammadi of the Structural Biology Faculty, with Andrew Beenken, explains "They show that the MAPK Fus3 is recruited to the Ste5-bound mitogen-activated protein kinase kinase (MAPICIC) Ste7, enabling Ste5 to unlock the A-loop conformation of Fus3 and turn it into a better substrate for Ste7." Plant Biology Faculty Member, Dominique Bergmann, feels this raises some questions about applying the idea to other organisms, including mammals. "SteS is a wonderful binary switch - allowing a single MAPKK to choose between two MAPKs. But what happens when a single MAPKK has more than two MAPK targets to choose from? This is the general situation in plants (Arabidopsis, for example, must contend with 10 MAPICICs and 20 MAPICs). How many activities might we find these scaffolds capable of that would allow them to discriminate among many potential targets?" Jane Endicott of the Cell Biology Faculty, believes "whatever the outcome of that future work, this paper will ensure a significant revising of our current models for how scaffold proteins work!" The structure of Faculty of 1000 Biology makes it possible to identify papers of broad interest, irrespective of the journal in which they are published. You can see the full comments of all the evaluating Faculty Members on this 'Must Read' Broad Impact paper by visiting the Faculty of 1000 Biology website. hack to ton Is your Institution the Best Place to Work in Academia? EFTA00775346 The Scientist's annual Best Places to Work in Academia survey is cientist Survey now open. Are you a tenured, permanent, or tenure-track scientist working in an academic, hospital, government or private organization? Do you think your organization is a great place to teach? To do research? Does it leave you personally fulfilled? What Take the survey now. areas could improve? The Scientist wants to hear what you think about your place of work. After all, a stellar institutional ranking for your employer reflects positively on you. If you're not satisfied, then this is your chance to voice your concerns anonymously. Institutions really do consider the results of this survey and listen. Complete the survey today and you'll also be entered to win a $250 Amazon gift card - but only if you respond by July 3, 2009. The results will be published in The Scientist's November 2009 issue. Help us help you - Tell your colleagues about the survey by passing this email around! The more responses we receive, the more accurate the results will be. Thank you for your time. We appreciate your contribution! See last year's results: 2008 Best Place to Work in Academia Survey results back to too Hidden Jewel: "Do your mice arrive with hidden baggage?" The authors of this enlightening paper, evaluated by Susan Akana of the Physiology Faculty look at the effect of shipping age of laboratory mice on later reproductive behaviour and make an interesting and worrying observation that could impact on reproductive behavioural studies. Susan writes "This paper clearly details that female mice shipped during the peripubertal period demonstrate a lower index of reproductive behaviour in mature adulthood." She notes the wide-reaching consequences of such a finding, aying that, "Because many laboratories purchase rodents at this age (5-6 weeks), it behooves investigators to re-inspect their own data and research models to ensure their experimental outcomes are not confounded or nuanced by these findings." She concludes "These studies are a strong cautionary note on interpreting rodent sexual behaviour without knowing the shipping history of the subjects." [See full evaluation] The Hidden Jewels lists are one of the most popular features on the Faculty of 1000 Biology site as they bring to scientists' attention papers they otherwise might have missed (especially EFTA00775347 in fields adjacent to their own). These lists are compiled daily and include highly viewed papers evaluated within the previous month. back to too F1000 on Twitter, Facebook and LinkedIn! Follow the Faculty of 1000 on Twitter: http://twittercom/f1000. Our ,;;Twitter Logo feed is open to all and contains breaking news, updates and links to specific evaluations that catch our eye 2,Facebook Logo FI000 is now on Facebook. Become a fan! litLinIcedIn Logo Join or start a discussion on our LinkedIn group. back to too Recommend F1000 to your librarian! Over 90% of the world's top institutions currently subscribe to F1000 Biology and many more are trialling. Why not visit the site to see if your own institute has access. If your institution does not have access, then please recommend the service to your library or institution so that they can arrange a free 30-day trial. You can use our online form to send your recommendation. If you prefer, there is a printable form (PDF). Alternatively, you may qualify for free access via HINARI or Faculty Member sponsorships: see http://www.f1000biology.comiabout/hinari. back to too Request some Faculty of 1000 Biology posters We have 4 poster designs! 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