EFTA01130829.pdf

SILK technology driven enterprise FIORENZO OMENETTO DAVID KAPLAN SILK LAB - TUFTS UNIVERSITY SI -K a K_J EFTA01130829  Silk is a natural fiber that has been cultivated in Far East Asia for over 5,000 years. The Chinese domesticated Bombyx mori caterpillars, and then harvested their cocoons in order to produce silk fiber to be used in luxurious textiles. As the material gained popularity in Europe and the Middle East, it eventually lent its name to the "Silk Road," the network of trade routes that connected Asia to Europe, arguably making silk the world's first globalized industry. Today, silk is still produced from the cocoons of these insects for use in textiles from haute couture to home decor, parachutes, and even surgical sutures. EFTA01130830  1. 2. raw materials boil with a salt and wash to remove the sericin (glue-like protein described on page 14) 3. 4. dissolve the silk in a remove the silk by dialysis second salt bath Product: a biocompatible solution of pure silk fibroin and water EFTA01130831 USE THE LIQUID SILK AS THE STARTING BLOCK FOR MANUFACTURING a addition of functional dopants electronics nanotech photonics optical fibers 47 I lib I adhesives bone ligaments microfluidics EFTA01130832  STRENGTHS CHALLENGES UNIQUE MATERIAL PERCEIVED VALUE Extreme versatility of material in formats Perception of silk as the next nylonTM and function including unusual operating or kevlarTM based on the unusual environments and unusual attributes, strength and toughness of the natural namely: fiber "an old story" sustainable material processing in water at room temperature biodegradable "with a clock" edible implantable in the human body microelectronic interfaces optical interfaces RESEARCH EXCELLENCE RAPIDLY GROWING COMPETITION Premier research group worldwide Danger of losing competitive edge - Resident knowledge base at Tufts Increasing foreign investment, UK, Strong links in place to DoD, Germany (>25M$ invested in 4 yrs), US and international labs India, China, Taiwan >70 people involved (research faculty, NEED FOR SCALE UP post-doc, PhD students) develop larger volumes of solution develop repeatable batches per application SILKLAB EFTA01130833  STRENGTHS CHALLENGES BEYOND BASIC RESEARCH BROAD PRODUCT SPACE Large and growing (spans consumer goods, pharma, medical, patent portfolio high-tech opto and electronic) numerous opportunities for translation licensing and starts ups underway Expensive to maintain/grow IP position BEYOND SCIENCE UN - FAO - sustainable farming no oil/petroleum consumption in fabrication no methane emission from discarding totally reintegrated in environment BEYOND EXPECTATIONS DEVELOPMENT RISK The unusual freedom to define both form and perceived as too risky for traditional function open unanticipated opportunities funding sources "valley of death" for private enterprise computing organs FDA approval for hybrid electronic/biomedical emo-tronics and the biomedical spaces edible technology biotic/abiotic interfaces personal distributed sensing the bio-cloud SILKLAB EFTA01130834  programmable forms beyond fibers - multiple material forms from the same starting point micro- and nanoparticles sponges and scaffolds films and conformal coatings hydrogels reversible/permanent adhesives blocks composites and fibers and ropes SILKLAB EFTA01130835 programmable functions beyond fibers - silk is a biomaterial thanks to processing and inorganic material features it allows unusual dopants combinations of properties organic dopants IF controlled degradation N edible implantable interfaces photonics/optoelectronics/ microelectronics/nanotech SILKLAB EFTA01130836  programmable forms programmable functions UNIQUE The unique MATERIAL combination of OUTCOMES attributes enables performance unobtainable with disruptive other materials thanks to the near- technology limitless ability to combine and recombine forms and functions DEVELOPING GAME-CHANGING APPLICATIONS and BUSINESSES WITH A MATERIAL THAT HAS BEEN VALIDATED WITH COMPELLING PRELIMINARY DATA and PROTOTYPES SILK LA B EFTA01130837  UNIQUE APPLICATION SPACES - BIOLOGICAL STABILIZATION films microneedle arrays particles gels IUI I I I • fibers Silk materials can entrain and function enzymes Vaccines preserve the biological viability of antibiotics samples at a monoclonal antibodies variety of hemoglobin temperatures therapeutics (-30 to 60 degC) — the materials can delivery / recovery of be recuperated by dissolving or stored components, consuming the silk sensors, pocket drugs, used for storage as pocket wound control.... needed. SILKLAB EFTA01130838 UNIQUE APPLICATION SPACES - NEW MODES TO ENCODE INFORMATION films microneedle arrays particles gels+particles fibers function bioactivated materials metal interfaces dissolvable information edible certification nanopatterns holograms/kinegrams holograms biological digital information communicators temporary beacons delivery / tracking / implantable RFIDs friend/foe tracking friend/foe ID distributed information C9c117KLAB EFTA01130839  UNIQUE APPLICATION SPACES - HUMAN WELFARE films microneedle arrays blocks/tablets gels+particles fibers AO! I L e-gels function bioactivated materials metal interfaces multipurpose materials edible hardware nanopatterns food and water quality flexible electronics fatigue sensors digital information personalized monitoring nutraceutical spray on wound stasis pharmaceutical military construction sensing adhesives clays/on-site molding Credit card pharmacy skin-mounted sensors SILKLAB EFTA01130840  UNIQUE APPLICATION SPACES - MEDICAL films microneedle arrays particles gels+particles fibers functior bioactivated materials metal interfaces wound stasis drug delivery nanopatterns next gen prosthetics holograms tissue regeneration digital information defect restoration on-surface devices delivery / tracking / (wound dressings) friend/foe sub-dermal devices neurological interfaces Soft interfaces bio-integrated sensors C9 cII1LAB EFTA01130841 SILK institute Government Grants Philantropic Inifts NM Corporate Donations r: P .§ = • time SILK INCMATOR Investment $ PRINCIPAL (IP) INVESTORS INVESTIGATORS & key personnel <6.11" for-profit Y% e pity (royalties) Z% equity The institute is owned by the university, scientists, and investors. All members of the institute have vested interest in its success. The institute builds value for the silk incubator which manages the silk IP. The incubator is within the institute and deals as the institute's own TLO The institute builds value for the silk incubator through technological progress. EFTA01130842 SILK INSTITUTE FOR INNOVATION AND NEW TECHNOLOGIES key assumptions : Silklab is the seed institute for innovation — it addresses technological challenges in basic and applied science to generate business and develop a biomaterials based array of startup industries. Silklab interfaces through its leadership with a dedicated technology transfer that liases with industry partners or entrepreneurs maximizing the ROI on the technology. Silklab always owns part of the startup companies that are generated from its technology development. Government Grants Philantropic Corporate Donations 2 Ps (3 2 1. Q 8 2 2 X tim SILK B Inyel tn- -a PRINCIPAL ECHNOLOGY TRANSFE INVESTORS 1 INVESTIGATORS (IP) & key personnel Y% equity for-profit Z% e uity EFTA01130843 SILK HOLDING COMPANY (II) leverage portfolio position and demonstrated prototypes sklau r .......r in Government Grants Philantropic Corporate Donations frastructure Z. Cr 03 c;".. X I< tim SILK INCYBATOR Inve tment $ PRINCIPAL (IP) 0 INVESTIGATORS & key personnel = Y% e uity Z% e uity (Prototype develo )ment) Y NEW Product 2 Product N INVESTORS additional equity percentage University Legacy revenues InvaMiggigig & New investment royalties EFTA01130844 SILK HOLDING COMPANY (III) silklaV Government Grants Philantropic Corporate Donations t SILK INCMATOR ment $ PRINCIPAL (IP) INVESTORS INVESTIGATORS & key personnel for-profit yok (royalties) uity (Prototype devel cosmetic NEW biological vascular Product N INVESTORS implants/fill k stabilizatio grafts ers n additional equity percentage refrigeratio r I IleSJ vaccines EFTA01130845  SILK HOLDING COMPANY (III) silk abr cosmetic biological vascular implants/fill stabilizatio grafts ers n refrigeratio le PEIWIPPs PERSONNEL PERSONNEL management 3 management 3 management 3 PhD/MD 3 PhD/MD 3 PhD/MD 3 technicians 2 technicians 2 technicians 2 clerical 2 clerical 2 clerical 2 10 +5 new hires) 10-15 by yr.3 10-15 by yr.3 EQUIPMEN FO%JIPMFNT 1=. 0 Product N titititi leverage common equipment and supplies for other T $ 5M/yr 5NT product developments and spinouts total 25M total 25M EFTA01130846 SILK- TECHNOLOGY TRANSFER AND DEVELOPMENT - BUSINESS OPPORTUNITIE Leverage versatility Silk a Develop parallel product lines that use the common biomaterial technology base to diversify and strengthen revenue opportunities Product N r ID/Security consumer Sensing biomedical Storage electronics goods food safety restoration of soft pharmaceutical Delivery BIO RFID electrolyte tissue defects (large) security/anti- bracelets glucose sensors silk mats-wound refrigeration free conformal tampering (Gatorade) (both antenna based dressing — bums storage of: electrodes/abiotic- individual pill and optical) vaccines biotic interfaces holograms/RFID- optical silk/filters light-activated tetracyclenes for sunscreen remote environmental antibodies organic electronic RFID signature cosmetics antibacterial gel sensing (chemical drugs interface — silk oxides (personalized proteiin glitter sensing reflective multifunctional pharmaceuticals for organic document security) tape) sutures ((fiber optic DNA semiconductors antibiotic filter RNA edible holographic masks for flu sutures, heating MRSA-hospital enzymes implantable/resorbabl film (food season sutures,therasuture) acquired infections e inductive power certification/organic (business plan +team nerve grafts delivery — enzyme and resorbable certification, ...) non-toxic toys exist) packages for electronics silk orthopedic controlled programmably edible smart-slides optical screws fermentation/ripenin technical dissolvable books/calendars- sensors/optical g (food industry?) edible/implantable holograms nutrition etc. assays) reversible surgical compnents (humidity- adhesive immobilization and holographic cosmetics stabilization of bio- storage of scents temporary RFID sensors)- product fluids (blood, saliva, bone and flavors tattoos (e.g. children contamination urine) for portable fillers/regeneration tracking in crowded analysis criaracl EFTA01130847 An argument for a new material platform Biomaterials have been in use for long in the human body to improve body functions and replace damaged tissues. These biodegradable biomaterials have evolved from biomaterials that do not react with the environment and easily dissolve in the body. Advances in technology and the emergence of innovative biomaterial products have enhanced the performance and applications of these biomaterials. Metals and ceramics dominate the biomaterials market. The global market for biomaterials is expected to reach $64.7 billion in 2015 from $25.6 billion in 2008 with a CAGR of 15% from 2010 to 2015. Biomaterial markets holds significant opportunity for innovators; an extensive research is required to develop new and improved products at competitive prices. With increase in the percentage of aging population worldwide, the number of individuals suffering from physical disability is also increasing. Baby boomers born between 1946 and 1964 are the major consumers of the biomaterial products. Besides, more than 20% of the global population in 2050 is expected to be over 60 years and this segment (of the population) will be significantly high in developing countries. This increase in the aging population will drive the demand for biomaterial products. EFTA01130848